![]() It affects both afferent and efferent components of parasympathetic and sympathetic innervation of the heart and has been detected in the early stages of both types of DM. CAN is the result of damage to nerve fibers that innervate the heart muscle and coronary arteries. In conclusion, the NPB/W signaling system is involved in the regulation of heart functions and long-term diabetes leads to changes in the expression of individual members of this signaling system differently in each cardiac compartment, which is related to the different morphology and function of these cardiac chambers.Ĭardiovascular autonomic neuropathy (CAN) belongs to a group of serious complications of diabetes, which exert a significant negative effect on the quality of life and survival of people with diabetes mellitus (DM). The positive inotropic effect of NPW described on the diabetic cardiomyocytes in vitro could point to a possible therapeutic target for compensation of the contractile dysfunction in the diabetic heart. The presence of NPBWR1 was also confirmed in a dissected LCM section of cardiomyocytes and coronary arteries. In the WB analysis, significant downregulation of NPBWR1 in LV (0.54-fold, p = 0.046) in diabetic rats was observed at the proteomic level. On the contrary, the expression of mRNA for NPBWR1 was downregulated in LV in diabetic rats. In the RT-qPCR analysis, we observed the upregulation of mRNA for preproNPB in RV, for preproNPW in LA, and for NPBWR1 in DRG in diabetic rats. The aim of the study is to investigate the impact of diabetes on the neuropeptide B/W signaling system in different heart compartments and neurons which innervates it. The location and function of NPB/W signaling systems have been predominantly detected and mapped within the CNS, including their role in the modulation of inflammatory pain, neuroendocrine functions, and autonomic nervous systems. Neuropeptide B (NPB) and neuropeptide W (NPW) are neuropeptides, which constitute NPB/W signaling systems together with G-protein coupled receptors NPBWR1. ![]()
0 Comments
Leave a Reply. |